※ Computational resources of MHC binding epitopes :
Last updated: November 26th, 2011
Major histocompatibility complex (MHC) molecules play an important role in the immune system through capturing peptide antigens for display on cell surfaces, while different types of MHC molecules bind distinct peptides. These peptide-MHC complexes are recognized by T cells via their T-cell receptors, which resulted in that T-cell recognition is thus restricted to those peptides that the MHC molecules can present. Therefore, prediction of peptides which could bind to MHC molecules is important for identification of peptides capable of eliciting a T-cell response.
We apologized that the computational studies without any web links of databases or tools will not be included in this compendium, since it's not easy for experimentalists to use studies directly. We are grateful for users feedback. Please inform Zexian Liu, Dr. Yu Xue or Dr. Jian Ren to add, remove or update one or multiple web links below.
8. MotifScan: HIV molecular immunology database.
9. HIV database: defined HIV epitopes.
10. dbMHC: A Database of DNA and clinical data related to MHC.
6. MHC2PRED: Prediction of promiscuous MHC II binders.
13. PREDEP: A MHC Class I epitope prediction.
17. MOTIF_SCAN: three functions: (1) find HLA anchor residue motifs within protein sequences for specified HLA genotypes, serotypes, or supertypes, (2) search any single protein for all known HLA anchor residue motifs, and (3) view motif libraries.
18. MULTIPRED: the prediction of peptide binding to multiple molecules (proteins) belonging to human leukocyte antigens (HLA) class I A2, A3 and class II DR supertypes. The tool is not available (Zhanget al., 2005).
26. EpiDirect: MHC II restricted T cell epitopes and ligands. The tool is not available..
27. EpiVaxb: MHC I and II conserved and promiscuous epitopes.
29. MHC bench: A server for evaluating MHC binding peptide prediction algorithms.